I had to bite the bullet and get off that stuff; I couldn't take the constipation any longer. I don't feel great and I am tempted at times to take it again but I refuse to turn back.
I slowly weaned myself off; that seemed to work pretty well. I still feel my absolute worst at night but am just dealing with it by going to bed early.
I hope other Zofran users are able to get off it soon; I feel for ya!